Figure 7
From: IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients
Stimulation of the supernatant cytokines IL-1β, IL-6, IL-7, IL-10, GM-CSF and TNF-α by stimulation with sham, amyloid-β, AI WT, AI G37R and fibrillar SOD-1 in sALS patients. Mutant SOD-1 induced 6 cytokines: IL-1β (P = 0.006; AI G37R vs. AI wild type SOD-1); interleukin-6 (P < 0.001; AI G37R vs. AI wild type SOD-1); IL-7 (P = 0.021; AI G37R vs. AI wild SOD-1); TNF-α (P < 0.001, AI G37R vs. AI wild type SOD-1); granulocyte-macrophage colony stimulating factor (P = 0.026, AI G37R vs. AI wild type SOD-1), and IL-10 (P = 0.026, AI G37R vs. AI wild type SOD-1).