Figure 5
From: Absence of IFNγ expression induces neuronal degeneration in the spinal cord of adult mice
Electron photomicrographs showing degenerated neurons in IFNγ-KO mice. (A) One abnormal motoneuron amongst of normal cell (arrow). Cytoplasm and nuclei are electron dense; there are invaginations in the nuclear and cytoplasmic membranes and presence of many vacuoles in the cytoplasm. (B) The cell body appears shrunken and the nuclear envelope fragmented. (C) Darkly stained cytoplasm, condensed nuclear chromatin, and some organelles are hardly visible. (D) Glial cells are in close contact with a degenerating neuron. Note phagocytes of ingested material in the cytoplasm of microglial cells. Scale bar: 2 μm.