Figure 2

S100B ablation reduces cortical microgliosis. Panel A contains representative photomicrographs of parasagittal cortical/hippocampal sections from 6 month old PSAPP and PSAPP/S100B^-/- mice stained with the microglial marker Iba1. Panel B contains high magnification images from consecutive sections co-stained Iba1 (brown) and Congo red (pink). Scale bars = 50 μm. The histograms in Panel C depict the mean Iba1 positive area ± SEM in PSAPP (black bars, n = 8), and PSAPP/S100B^-/- (red bars, n = 6), mice. Asterisks denote p ≤ 0.05 when compared to the PSAPP group. Panel D is a scatter plot of the mean Iba1 burden versus plaque load for each animal (cortex and hippocampus).