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Figure 3 | Journal of Neuroinflammation

Figure 3

From: PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation

Figure 3

S100B ablation reduces cortical astrocytosis. Panel A contains representative photomicrographs of parasagittal cortical/hippocampal sections from 6 month old PSAPP and PSAPP/S100B-/- mice shown stained with the astrocytic marker a GFAP. Panel B contains high magnification images from consecutive sections co-stained Iba1 (brown) and Congo red (pink). Scale bars = 50 μm. The histogram in Panel C illustrates the mean GFAP positive area ± SEM in PSAPP (black bars, n = 8), and PSAPP/S100B-/- (red bars, n = 6) mice. Asterisks denote p ≤ 0.05 when compared to the PSAPP group. Panel D is a scatter plot of the mean GFAP burden versus plaque load for each animal (cortex and hippocampus).

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