Figure 1

IgG antibody response to MOG in serum and CSF. Serum (A) and CSF (B) IgG antibody response to MOG in patients with HIV associated neurocognitive disorder (HAND), HIV patients with opportunistic infections of the CNS (HIVOI), HIV meningitis (HIVM), asymptomatic HIV infection (HIVasy), other infectious neurological diseases (OIND) and other neurological diseases (OND). Kruskal Wallis test (A: p < 0.01, B: p < 0.001). Dunn's post hoc test yielded a significant difference between HAND and OND patients (p < 0.01, A). The dotted line indicates a cut-off value of 0.6 OD, which is considered as serum immunopositivity for MOG IgG. In CSF samples Dunn's post hoc test yielded a significant difference of HAND and HIVOI patients compared to HIVasy (p < 0.05 and p < 0.01) and OND patients (both p < 0.001) and OIND compared to OND patients (p < 0.01). Data is shown on a logarithmic scale; the horizontal bar represents the median.*, p < 0.05; **, p < 0.01; ***, p < 0.001.