Figure 3From: Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosisRegional changes in CD11b expression in spinal cord. Changes in the extent and intensity of DAB-stained CD11b expression in spinal cord of hmSOD1 rats as a function of age or disease stage. (A, B) The extent of CD11b expression relative to age-matched wild-type levels is expressed as a function of age. Linear regression slopes in the ventral horns of 0.12 ± 0.018 at the cervical-thoracic level and 0.15 ± 0.028 at the lumbar level (A). Linear regression slopes in the ventrolateral white matter are 0.05 ± 0.011 at the cervical-thoracic level and 0.069 ± 0.0107 at the lumbar level (B). (C, D) The average extent (C) and intensity (D) of CD11b expression relative to wild-type levels in spinal cord regions expressed as a function of disease stage. Bars represent average + SEM. #, significantly different compared to wild-type levels (P < 5 × 10-5, Neuman-Keuls test). *, significantly different compared to levels from only age-matched wild-type rats (P < 0.05, unpaired T test).Back to article page