Figure 4

Changes in CD11b expression in nerve roots and sciatic nerve. Changes in the extent of DAB-stained CD11b expression in lumbar nerve roots and sciatic nerves of hmSOD1 rats. (A,B) The extent of CD11b expression relative to age-matched wild-type levels is expressed as a function of age. Linear regression slopes are 1.7 ± 0.45 in the ventral nerve roots (A) and 0.21 ± 0.063 in the sciatic nerve (B). (C) The average extent of CD11b expression relative to wild-type levels is expressed as a function of disease stage. Bars represent average + SEM. ND, not determined. #, significantly different compared to wild-type levels (P < 0.0005, Neuman-Keuls test). *, significantly different compared to levels from only age-matched wild-type rats (P < 0.05, unpaired T test).