Figure 2

Effects of FGF-2 and BDNF on hippocampal Ox42-positive cells (putative microglia). (A-C) Time course of the alterations in Ox42 expression, expressed as percent of Ox42-positive pixels. See Figure 1 for details. Data are presented as mean ± s.e.m. for 6 animals per group. *P < 0.05, **P > 0.01 versus naïve; ^●P < 0.05, ^●●P < 0.01 versus pilo-control vector. One-way ANOVA and post-hoc Newman-Keuls test. (D-F) Representative sections showing Ox42 immunohistochemistry in the CA1 region of naïve rats (D), of pilocarpine rats killed 11 days after control vector injection (E) and of pilocarpine rats 11 days after FGF2-BDNF vector injection (F). The pattern of changes observed in CA1 was identical for the entire hippocampus. Horizontal bar = 50 μm.