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Table 1 Plasma cytokines 4 h after LPS in mice exposed to MA.

From: A neurotoxic regimen of methamphetamine exacerbates the febrile and neuroinflammatory response to a subsequent peripheral immune stimulus

  0 mg/kg MA 5 mg/kg MA p
  Saline LPS Saline LPS MA LPS MA × LPS
IL-1β 124.63 ± 47.25 253.4 ± 47.48 226.77 ± 10.97 135.57 ± 12.7 0.82 0.59 0.0078#
IL-6 36.61 ± 11.41 662.74 ± 426.8 33.54 ± 9.27 1557.7 ± 196.1 0.08 0.006* 0.08
TNFα 278.61 ± 78.1 501.02 ± 106.5 268.05 ± 33.3 225.49 ± 32.7 0.06 0.22 0.08
IL-10 107.89 ± 28.2 220.43 ± 33.9 111.0 ± 10.57 287.12 ± 69.4 0.42 0.005* 0.46
  1. Mice were given four injections of saline or MA (5 mg/kg) i.p. at 2 h intervals. Twenty-four hours after the first MA injection, mice were given either saline or LPS (100 μg/kg) and blood was collected at 4 h post-injection. *p < 0.01, different from saline controls. #p < 0.01 MA × LPS interaction