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Table 1 Plasma cytokines 4 h after LPS in mice exposed to MA.

From: A neurotoxic regimen of methamphetamine exacerbates the febrile and neuroinflammatory response to a subsequent peripheral immune stimulus

 

0 mg/kg MA

5 mg/kg MA

p

 

Saline

LPS

Saline

LPS

MA

LPS

MA × LPS

IL-1β

124.63 ± 47.25

253.4 ± 47.48

226.77 ± 10.97

135.57 ± 12.7

0.82

0.59

0.0078#

IL-6

36.61 ± 11.41

662.74 ± 426.8

33.54 ± 9.27

1557.7 ± 196.1

0.08

0.006*

0.08

TNFα

278.61 ± 78.1

501.02 ± 106.5

268.05 ± 33.3

225.49 ± 32.7

0.06

0.22

0.08

IL-10

107.89 ± 28.2

220.43 ± 33.9

111.0 ± 10.57

287.12 ± 69.4

0.42

0.005*

0.46

  1. Mice were given four injections of saline or MA (5 mg/kg) i.p. at 2 h intervals. Twenty-four hours after the first MA injection, mice were given either saline or LPS (100 μg/kg) and blood was collected at 4 h post-injection. *p < 0.01, different from saline controls. #p < 0.01 MA × LPS interaction
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Journal of Neuroinflammation

ISSN: 1742-2094