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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells

Figure 6

Down-regulation of LPS-induced COX-2 expression and PGE 2 production by HO-1/CO in bEnd.3 cells. LPS-induced COX-2 expression and PGE2 production were mediated by a TLR4/MyD88/NF-κB pathway. Induction of HO-1 by pretreatment with CoPP or infection with Adv-HO-1 attenuated LPS-induced COX-2 expression and PGE2 production in bEnd.3 cells. A HO-1 by-product, CO, at least in part, attenuated LPS-induced COX-2 expression through interruption of TLR4/MyD88/NF-κB pathway in bEnd.3 cells.

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