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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Microglial activation state exerts a biphasic influence on brain endothelial cell proliferation by regulating the balance of TNF and TGF-β1

Figure 1

Regulation of BEC proliferation by microglial-conditioned medium. A. Dual immunocytochemistry for BrdU and Hoechst demonstrated that BEC proliferation was inhibited by conditioned media from resting microglia (MG-CM (rest)), but promoted by conditioned media from activated microglia (MG-CM (activ)). Scale bar = 100 μm. B. Quantification of BEC proliferation in response to microglia-conditioned media (MG-CM) and astrocyte-conditioned media (A-CM). BEC proliferation was examined over 16 hours, and expressed as the percentage of BEC that incorporated BrdU; all points represent the mean ± SEM of 4 experiments. MG-CM from resting or activated microglia, inhibited or promoted BEC proliferation, respectively. A-CM from resting and activated astrocytes both inhibited BEC proliferation. p < 0.05.

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