Figure 4
From: A role for spleen monocytes in post-ischemic brain inflammation and injury
Effect of MFX on post-ischemic inflammation and injury in the brain. MCP-1 mRNA (A) and CCR2 mRNA (B) levels were measured in the 7 d post-ischemic brain in vehicle (Veh) and MFX treated mice. CCR2 mRNA level (B) was decreased by MFX, and MCP-1 was not significant between Veh and MFX treatment (A). β-actin was used as internal control and data were normalized with the contralateral side in Veh group. Values were expressed as mean ± SEM. Contl, contralateral side; Ipsl, ipsilateral side. ** p < 0.01 and *** p < 0.001 compared to contralateral side; # p < 0.05 compared to Veh; NS, not significant. n = 6-8/group. C, Infarct volume measurement 7 d after MCAO. Values were present as mean ± 95% Confidence interval. * p < 0.05 compared to Veh. n = 12-15/group.