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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide

Figure 1

LPS injection caused exaggerated social withdrawal in CX 3 CR1-/- mice. A) CX3CR1+/- (Control) or CX3CR1-/- (KO) mice were injected i.p. with saline or LPS (0.5 mg/kg) and social exploratory behavior was measured before LPS injection and again 4, 8, 12 and 24 h later. Graph represents the mean ± SEM (n = 10). Means with * are significantly different (P < 0.05) from respective saline-treated controls and means with ‡ are significantly different from Control LPS. B) Body weight and C) food intake were determined before i.p. LPS injection and again 4, 8, 12, and 24 h later. Because there was no significant effect of genotype, data were collapsed to show the main effect of LPS. Bars represent the mean ± SEM (n = 10). Means with * are significantly different (P < 0.05) from saline controls.

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