Figure 2

LPS injection caused an exaggerated increase in IL-1β in the brain and plasma of CX ₃ CR1^-/- mice. CX₃CR1^+/- (Control) or CX₃CR1^-/- (KO) mice were injected i.p. with saline or LPS (0.5 mg/kg) and IL-1β protein levels determined in the A) cortex and B) plasma collected 4 h after injection. Bars represent the mean ± SEM. Means with different letters (a, b, or c) are significantly different (P < 0.05) from each other. In a related study, mice were treated as above and CX₃CL1 protein levels were determined in the C) cortex and D) plasma collected 4 h after injection. Bars represent the mean ± SEM. Means with different letters (a, b, or c) are significantly different (P < 0.05) from each other