Figure 3
Amplified IL-1β IDO and KMO mRNA induction in microglia of CX 3 CR1-/- mice following peripheral LPS injection. CX3CR1+/- (Control) or CX3CR1-/- (KO) mice were injected i.p. with saline or LPS (0.5 mg/kg) and A) IL-1β, B) TNFα, C) TLR2, D) CD14, E) CD11b, F) IDO and G) KMO mRNA levels determined from enriched microglia isolated 4 h after LPS injection. Bars represent the mean ± SEM. n.d. = values were non-detectable. Means with different letters (a, b, or c) are significantly different (P < 0.05) from each other.