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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide

Figure 4

Prolonged IL-1β, TLR2 and CD14 expression in microglia of CX 3 CR1-/- mice following peripheral LPS injection. CX3CR1+/- (Control) or CX3CR1-/- (KO) mice were injected i.p. with saline or LPS (0.5 mg/kg) and A) IL-1β, B) TNFα, C) TLR2, D) CD14 mRNA and E) CD11b levels were determined in enriched microglia isolated 24 h after LPS injection. Bars represent the mean ± SEM. Means with different letters (a, b, or c) are significantly different (P < 0.05) from each other. In a related study, control or KO mice were injected i.p. with saline or LPS and surface expression of CD14 protein on microglia was determined. F) Representative histograms of CD14 expression on microglia following experimental treatments. G) Mean fluorescence Intensity (M.F.I.) of CD14 expression on microglia (GFP+/CD45low) following experimental treatments. Bars represent the mean ± SEM (n = 6). Means with different letters (a, b, or c) are significantly different (P < 0.05) from each other.

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