Figure 6

Depression-like behavior was prolonged in CX ₃ CR1^-/- mice following peripheral LPS injection. CX₃CR1^+/- (Control) or CX₃CR1^-/- (KO) mice were injected i.p. with saline or LPS (0.5 mg/kg) and A) locomotor activity was determined 24, 48, and 72 h later. Bars represent the mean ± SEM (n = 10-12). Means with * are significantly different (P < 0.05) from LPS-treated group. B) Mice were treated as above and resignation was determined in the tail suspension test B) 48 (n = 16) and 72 h (n = 10) after injections. Bars represent the mean ± SEM. Means with * are significantly different (P < 0.05) from all other treatments.