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Figure 4 | Journal of Neuroinflammation

Figure 4

From: β-Adrenoceptor activation depresses brain inflammation and is neuroprotective in lipopolysaccharide-induced sensitization to oxygen-glucose deprivation in organotypic hippocampal slices

Figure 4

Effect of β1-specific antagonist CGP 20712A or the specific-β2 antagonist ICI 118551 on the protective effect of dobutamine on neuronal cell death following lipopolysaccharide-induced sensitization to OGD in murine hippocampal slice cultures. Cell death (MFI) after 24 h LPS + 15 min OGD (white bars), dobutamine (5 μM) +24 h LPS +15 min OGD (black bars), dobutamine (5 μM) + CGP 20712A (5 μM) + 24 h LPS + 15 min OGD (light shaded bars), dobutamine (5 μM) + ICI 118551 (5 μM) + 24 h LPS + 15 min OGD (dark shaded bars), at repeated points of recovery. Data are shown as means ± SEM with n = 18. Dobutamine (5 μM) + LPS + OGD versus LPS + OGD, p < 0.01 in the CA1; dobutamine (5 μM) + CGP 20712A (5 μM) + LPS + OGD versus dobutamine (5 μM) + LPS + OGD, p < 0.01 in the CA1; dobutamine (5 μM) + ICI 118551 (5 μM) + LPS + OGD versus dobutamine (5 μM) + LPS + OGD, p < 0.01 in the CA1 Repeated-measures ANOVA with post hoc Bonferroni.

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Journal of Neuroinflammation

ISSN: 1742-2094