Skip to main content
Figure 2 | Journal of Neuroinflammation

Figure 2

From: Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy

Figure 2

Effects of GTS on LPS-induced depression-like behavior and corticosterone release. Mice were treated as in Fig.1. Locomotor activity, expressed as rearings numbers and movement numbers (Figure.2A, n = 10 mice each group), was assessed before the tail suspension test (TST) and the forced swimming test (FST). The sucrose preference test was measured 24 h following administration of LPS (Figure.2B, n = 6 mice each group). Immobility time was assessed during the FST (Figure.2C, n = 10 mice each group) and the TST (Figure.2D, n = 10 mice each group) 22 h and 24 h post-LPS injection. Corticosterone profiles in different groups which were determined 4 h post LPS or saline challenge (Figure.2E, n = 8 mice each group C). The data are expressed as mean ± SEM. For statistical significance, a: p < 0.01 compared with the vehicle/saline group, b: p < 0.05 compared with the vehicle/LPS group. c: p < 0.01 or p < 0.05 compared with the LPS/GTS group.

Back to article page