The treatment with UCM-707 inhibits VCAM-1 expression in TMEV-infected mice. Study with Cnr1+/+ and Cnr1-/- mice. Both, TMEV-infected and Sham mice were treated with UCM-707 (3 mg/kg) or the corresponding vehicle (n = 3 for each group) immediately after virus infection for three consecutive days. Analysis were performed using representative microphotographs of coronal brain sections (30 μm) of ipsilateral (A) or contralateral (C) brain tissue close to the virus side of injection, immunostained for VCAM-1. Arrows indicate VCAM-1 immunostaining. Scale bar is 50 μm. (B, D) Quantification of intensity of VCAM-1 staining as described in Material and methods in the ipsilateral or contralateral hemispheres, respectively. ND, non detected; **p < 0.01 vs. Sham (Cnr1+/+); ##p < 0.01 vs. Sham (Cnr1-/-); ++p < 0.01 vs. TMEV+vehicle (Cnr1+/+); &p < 0.05 vs. TMEV+vehicle (Cnr1-/-); Xp < 0.05 vs. TMEV+UCM-707 (Cnr1+/+).