The treatment with UCM-707 decreases microglia reactivity in TMEV-infected mice. Study with Cnr1+/+ and Cnr1-/- mice. Both TMEV-infected and Sham mice from both strains (Cnr1+/+ and Cnr1-/-) were treated with UCM-707 (3 mg/kg) or the corresponding vehicle (n = 3 for each group) immediately after the virus infection for three consecutive days. (A) Coronal brain section level for the analysis of CD11b+ expression. (B) Representative micrographs of ipsilateral cerebral cortex in sham, TMEV-infected plus vehicle or TMEV infected plus UCM-707 from Cnr1+/+ or Cnr1-/- mice. (C) Quantification of percentage of area occupied by microglia per field is represented. Scale bar is 50 μm. **p < 0.01 vs Sham (Cnr1+/+); ++p < 0.01 vs. TMEV+vehicle (Cnr1+/+); ##p < 0.01 vs Sham (Cnr1-/-); &p = 0.07 vs. TMEV+vehicle (Cnr1-/-).