Figure 3

Early physiological changes after SAH: Animals were either untreated or were treated with vinblastine, anti PMN serum, or PDTC. ICP, CBF and BP were measured in real time from 20 minutes prior and 60 minutes post SAH (see methods). In A: note that ICP peak is similar in all groups but ICP decline in anti PMN group is significantly higher (25 ± 8 mmHg) than the untreated SAH animals (13 ± 1 mmHg). In B note that CAF fall and 60 minutes recovery is similar among animal groups. In C note that baseline BF and the transient increase in BP at SAH was similar among groups. There after BP decreased to lower levels in vinblastine and PDTC treated but not in anti PMN treated animals. Data are mean ± sem, N is 5-7 animals per treatment group. * significantly different at p < 0.05 from time matched untreated SAH animals.