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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Cigarette smoke extract upregulates heme oxygenase-1 via PKC/NADPH oxidase/ROS/PDGFR/PI3K/Akt pathway in mouse brain endothelial cells

Figure 7

PPCSE induces HO-1 expression through PDGFR/PI3K/Akt cascade in a PC-PLC/PKCδ/NADPH oxidase/ROS-dependent manner in bEnd.3 cells. Schematic diagram illustrating the proposed signaling pathway involved in PPCSE-induced HO-1 expression in bEnd.3 cells. PPCSE-induced HO-1 expression is mediated by PC-PLC/PKCδ/NADPH oxidase/ROS-dependent PDGFR/PI3K/Akt cascade.

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