Figure 5
Subchronic DE Exposure Elevates Aβ in the Frontal Lobe. Male Fischer 344 rats were exposed to either filtered air (control, 0 μg PM/m3 DE, n = 8), 35 μg PM/m3 DE (Low, n = 8), 100 μg PM/m3 DE (Mid Low, n = 8), 311 μg PM/m3 DE (Mid High, n = 8), or 992 μg PM/m3 DE (High, n = 8) for 6 months. Aβ42 protein levels were measured in the frontal lobe ELISA. An * indicates significant difference (p < 0.05) from control animals. DE elevated Aβ42 protein levels in the frontal lobe at only the highest concentrations tested, demonstrating that subchronic exposure to high levels of air pollution is associated with Alzheimer's disease-like pathology.