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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice

Figure 8

Schematic drawing of hypothesis how TIMP-3 facilitates immature OL death after transient focal cerebral ischemia in mouse. Route 1: TIMP-3 could block the shedding of various members of the death receptor families, including TNFR-1, by inhibiting TACE, stabilizing the death receptor on the surface of OLs. Route 2: Later (3 days reperfusion; RP), TIMP-3 enhances the inflammatory response and the release of inflammatory mediators in glial cells including TNF-α and MMP-3, which promote the OL death through a TNF-α-mediated mechanism.

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Journal of Neuroinflammation

ISSN: 1742-2094