Treatment of BV2 microglial cells with immune complexes leads to induction of components of the MMP2 and MMP9 systems. Panels A and C show the average (± SEM) mRNA levels of the MMP2 (A) and MMP9 (C) systems in BV2 cells treated with IgG, Abeta, Abeta immune complexes (Abeta IC) or tau immune complexes (tau IC) for 24 hours. Data are shown as fold change compared to untreated sister BV2 cultures. * indicates P < 0.05, ** indicates P < 0.01 compared to untreated BV2 cells. Panels B and D show protein expression as measured by sandwich ELISA for components of the MMP2 (B) and MMP9 (D) systems. * indicates P < 0.05, ** indicates P < 0.01 compared to untreated BV2 cells.