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Table 1 Summary of previously published data for anti-Aβ immunotherapy studies.

From: Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence

Study Mouse model Age (mo) Histopathology Cognition
    CAA Micro-hemorrhage  
Passive immunization APPSw 19-22 ↓60% ↑ 4-fold ↑ 6-fold Improved
Active vaccination APPSw/
NOS2-/-
12-16 ↓85% No change ↑ 10-fold Reversed