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Table 1 Summary of previously published data for anti-Aβ immunotherapy studies.

From: Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence

Study

Mouse model

Age (mo)

Histopathology

Cognition

   

Aβ

CAA

Micro-hemorrhage

 

Passive immunization

APPSw

19-22

↓60%

↑ 4-fold

↑ 6-fold

Improved

Active vaccination

APPSw/

NOS2-/-

12-16

↓85%

No change

↑ 10-fold

Reversed

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Journal of Neuroinflammation

ISSN: 1742-2094