Figure 10

Gelsolin restores suppressed T lymphocyte function after burn injury. Splenic mononuclear cells harvested from the mice under different treatments were cultured in the presence of the T-cell mitogen concanavalin A (5 mg/L) for 48 h. T-cell viability was determined by MTT methods (A) and the supernatants were collected for IL-2 analysis (B). Data are shown as mean ± SD for n = 6-8. *P < 0.05 vs. intact control; #p < 0.05 vs. sham-injured mice; &p < 0.05 vs. placebo mice by ANOVA, Newman-Keuls post-hoc test.