Figure 4

Gelsolin administration protects against burn-induced proinflammatory cytokine expression in brain. Elevated levels of IL-1β (A) and IL-6 (B) mRNA, as well as HMGB1 content (C) were found in cortex after burn injury. Data are shown as mean ± SD for n = 6. *P < 0.05 and **P < 0.01 vs. sham-injured mice; #p < 0.05, ##p < 0.01, ### p < 0.001 vs. placebo mice; +p < 0.05 and ++p < 0.01 vs. Gsn-L by ANOVA, Newman-Keuls post-hoc test.