Figure 7
Gelsolin affects migration of myeloid-derived cells into brain. CD11b+ cells from mice 72 h postburn (A) and quantification of infiltrating CD11b+ (B) cells in 10 high power fields (HPF) of the periventricle region following gelsolin treatment. Gelsolin positive cells were seen in medial habenular nucleus (MHb, a), hippocampal CA field (CA2, b), corpus callosum (cc, c), bed nucleus striatum terminal (BST, d), choroid plexus (e), cortex (f), lateral ventricle (g, h) and amplified lateral ventricle (g', h'). Magnifications for "a-f" and "g'-h'" are × 400, "g-h" are × 200. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. sham-injured mice; #p < 0.05, ## p < 0.01, ### p < 0.001 vs. placebo mice; ++p < 0.01, and +++p < 0.001 vs. Gsn-L mice by ANOVA, Newman-Keuls post-hoc test. Data are means ± SD for n = 6-8.