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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia

Figure 4

ROS contribute to cytokine and chemokine production by microglia in response to viral infection. Supernatants were collected from murine microglial cell cultures pretreated with DPI or APO at the indicated concentrations for 1 h prior to viral exposure for 36 h (or 16 h for TNF-α) and cytokine and chemokine levels were assessed using ELISA for A) TNF-α; B)IL-1β; C) CCL2; and D) CXCL10. Data are presented as mean ± SD of 3 replicates from 3 separate experiments. **p < 0.01 vs. uninfected control; p < 0.05 and ††p < 0.01 vs. HSV alone.

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