Curcumin is a potent modulator of microglial gene expression and migration

Table 2 Differentially expressed transcripts after 6 h stimulation of BV-2 cells with 20 μM curcumin

Nr	ID	Symbol	Gene Name	FC
UP-REGULATED
1	80883	Ntng1	Netrin G1	313.0
2	18613	Pecam1	Platelet/endothelial cell adhesion molecule 1	42.8
3	13388	Dll1	Delta-like 1	35.5
4	12824	Col2a1	Collagen, type II, alpha 1	21.6
5	14103	Fasl	Fas ligand (TNF superfamily, member 6)	12.8
6	12653	Chgb	Chromogranin B	11.9
7	66184	Rps4y2	Ribosomal protein S4, Y-linked 2	9.7
8	69816	Perp1	RIKEN cDNA 2010001M09 gene	9.7
9	16992	Lta	Lymphotoxin A	9.4
10	19206	Ptch1	Patched homolog 1	5.9
11	19013	Ppara	Peroxisome proliferator activated receptor alpha	4.6
12	109685	Hyal3	Hyaluronoglucosaminidase 3	4.5
13	20997	T	Brachyuri	4.2
14	17246	Mdm2	Transformed mouse 3T3 cell double minute 2	3.1
15	14102	Fas	Fas	2.8
16	14183	Fgfr2	Fibroblast growth factor receptor 2	2.7
17	13645	Egf	Epidermal growth factor	2.2
18	14179	Fgf8	Fibroblast growth factor 8	2.1
19	20655	Sod1	Superoxide dismutase 1	2.1
20	14526	Gcg	Glucagon	2.0
DOWN-REGULATED
1	24088	Tlr2	Toll-like receptor 2	-6.9
2	18505	Pax3	Paired box gene 3	-6.6
3	14281	Fos	FBJ osteosarcoma oncogene	-4.4
4	11622	Ahr	Aryl-hydrocarbon receptor	-4.1
5	16835	Ldlr	Low density lipoprotein receptor	-3.8
6	13654	Egr2	Early growth response 2	-3.5
7	68010	Bambi	BMP and activin membrane-bound inhibitor	-3.3
8	12048	Bcl2l1	BCL2-like 1	-3.3
9	19225	Ptgs2	Prostaglandin-endoperoxide synthase 2	-3.0
10	20296	Ccl2	Chemokine (C-C motif) ligand 2	-2.8
11	12393	Runx2	Runt related transcription factor 2	-2.8
12	17311	Kitl	Kit ligand	-2.4
13	16869	Lhx1	LIM homeobox protein 1	-2.4
14	12977	Csf1	Colony stimulating factor 1	-2.4
15	20528	Slc2a4	Solute carrier family 2, member 4	-2.2

Significance analysis of triplicate microarrays was performed with a false discovery rate of 0.1%. ID, Entrez Gene ID; FC: Fold change.

ISSN: 1742-2094