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Figure 14 | Journal of Neuroinflammation

Figure 14

From: Expression of sphingosine kinase 1 in amoeboid microglial cells in the corpus callosum of postnatal rats

Figure 14

Number, intensity and mRNA expression in IL-1β-positive AMC after different treatments. Quantitative analysis shows that there is a significant reduction in the number of IL-1β-positive AMC in rats injected with DMS+LPS when compared to that in rats injected with LPS alone (A). Further, the intensity of IL-1β immunofluorescence is decreased in rats injected with DMS+LPS when compared to that in rats injected with LPS alone (B). RT-PCR analysis demonstrates that IL-1β mRNA expression is increased significantly in primary microglial cells in vitro treated with LPS, and that concomitant treatment with DMS prevented this increase in IL-1β (C). Data are presented as mean ± S.E, Control vs LPS, ** P < 0.01

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