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Figure 15 | Journal of Neuroinflammation

Figure 15

From: Expression of sphingosine kinase 1 in amoeboid microglial cells in the corpus callosum of postnatal rats

Figure 15

OX-42 (Aa, Ba, Ca) and NFkB (Ab, Bb, Cb) expression in 5-d-old rats receiving saline, LPS or DMS + LPS injection and sacrificed 1 h later. NFkB immunoexpression in AMC found in corpus callosum is clearly enhanced in LPS-injected rats (Ba-c) when compared with control rats (Aa-c). Decreased NFkB immunoexpression in AMC is observed in DMS + LPS-injected rats (Ca-c). Co-expression of OX-42 and NFkB is evident in merged images in Ac, Bc and Cc (arrows). Moreover, nuclear translocation of NFκB appears to be more evident and significantly increased in AMC of LPS-injected rats (Bb) when compared with that of control rats or rats injected with LPS+DMS (Fig. Ab, Cb). Nuclei are stained with DAPI. Scale bar = 20 μm.

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