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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Expression of sphingosine kinase 1 in amoeboid microglial cells in the corpus callosum of postnatal rats

Figure 2

Isotypic control for SphK1 immunoreactivity. Sections incubated with rabbit IgG as an isotypic control for anti-SphK1 do not show any immunoreactivity, confirming the specificity of SphK1 immunoreactivity (Aa-c). Nuclei of all cells are stained with DAPI. Quantitative analysis shows that the frequency of SphK1-positive AMC decreases progressively with advancing age. The majority of AMC in 1-5-d-old rats are SphK1 positive. The number of SphK1-positive cells decreased by age 7-14 d (B). Likewise, SphK1 immunofluorescence intensity is attenuated with advancing age (C). Scale bar = 50 μm

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