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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells

Figure 1

SB623 cells proliferate more slowly and express more p16Ink4A than parental MSCs. A) Cell proliferation assessed by cell counts (with trypan blue exclusion; left plot) and the percentage of G0/G1 cells measured by propidium iodide staining (middle plot) reveal a significant reduction in proliferation for SB623 cells compared to parental MSCs (*p < 0.05; n = 6); Far right shows representative FACS data for determining cell cycle profile. B) Cell division kinetics assessed by CFSE dilution and p16Ink4A protein by intracellular flow cytometry show a significant increase in p16Ink4A in SB623 cells versus parental MSCs (*p < 0.05); Representative FACS data on left and the mean expression for 4 different matched lots of MSC and SB623 cells on right.

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