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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Comparing the immunosuppressive potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells

Figure 3

MSC and SB623 attenuate T cell activation and proliferation in human allogeneic mixed lymphocyte reaction. CFSE-labeled human enriched T cells plus allogeneic PBMCs were cultured with or without MSCs or SB623 cells. A) CD69 on day 2, B) non-dividing T cells (M1 gating on CFSE-high cells), and C) The percentage of cells expressing HLA-DR were assessed on day 5 by flow cytometry. Representative FACS data and the mean expression for 3 different matched lots of MSC and SB623 cells are shown. *p < 0.05 versus T cells alone; #p < 0.05 versus MLR.

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