Table 3 Comparisons of cytokine levels between fever only control and febrile seizure subgroups
From: Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures
Groups (No.) | IL-1β | IL-6 | HMGB1 | IFN-γ | TNF-α | IL-10 |
|---|---|---|---|---|---|---|
| Â | (pg/mL) | (pg/mL) | (ng/mL) | (pg/mL) | (pg/mL) | (pg/mL) |
Fever only control (41) | 3.1 ± 0.8†| 134.0 ± 22.7 | 24.8 ± 2.5 | 84.2 ± 38.6 | 5.6 ± 2.9 | 8.3 ± 2.6 |
Febrile seizures (41) | 12.0 ± 5.3* | 247.1 ± 43.0 | 32.6 ± 3.0* | 73.5 ± 20.9 | 5.0 ± 1.8 | 23.6 ± 13.4 |
   Typical FS (27) | 12.9 ± 7.6* | 260.1 ± 50.4* | 30.5 ± 3.8 | 66.5 ± 21.6 | 3.0 ± 0.9 | 28.5 ± 20.3 |
   Atypical FS (14) | 10.4 ± 4.9 | 228.3 ± 81.2 | 36.6 ± 5.0* | 86.9 ± 45.9 | 9.0 ± 5.0 | 14.2 ± 3.8 |
   First FS (28) | 3.7 ± 0.7 | 252.7 ± 53.5 | 35.0 ± 3.9* | 74.6 ± 21.3* | 1.9 ± 0.6 | 9.2 ± 2.2 |
   Recurrent FS (13) | 30.1 ± 15.7 | 241.7 ± 73.0 | 27.3 ± 4.7 | 70.9 ± 48.8 | 11.8 ± 5.3 | 54.6 ± 41.8 |
   FS without FHx (30) | 13.0 ± 6.9 | 241.6 ± 49.3 | 31.8 ± 3.6 | 62.8 ± 22.5 | 5.2 ± 2.4 | 29. 4 ± 18.2* |
   FS with FHx (11) | 9.4 ± 5.6 | 270.1 ± 89.2 | 34.7 ± 5.9 | 102.6 ± 48.5 | 4.7 ± 2.1 | 7.8 ± 2.7 |