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Figure 2 | Journal of Neuroinflammation

Figure 2

From: The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration

Figure 2

MyD88-/- mice have MPTP-induced dopaminergic striatal terminal degeneration. (A) Striatal measurements of DAT binding, as assessed by [125I]-RTI-121 autoradiography, revealed a significant decrease both in WT and MyD88-/- mice, as compared to vehicle treated WT and MyD88-/- mice (p < 0.001). (B) Western blot analysis of TH protein expression in the striatum further demonstrated a loss of dopaminergic fibers in both MPTP-treated groups (p < 0.001). Statistical analyses were performed using one-way ANOVA. ***p < 0.001. Scale bar in A = 1 mm. Abbreviations: S: saline-treated; M: MPTP-treated.

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