Figure 3

Dopaminergic neurons are not protected from MPTP in MyD88-/- mice. (A) Stereological counts of TH+ cells in the SNpc showed a decrease in dopaminergic neuronal count in WT mice that received MPTP, as compared to saline-treated WT mice (p < 0.05). MyD88-/- mice treated with MPTP were as vulnerable as WT, displaying a similar loss of dopaminergic neurons (p < 0.05). (B) Photomicrographs of TH immunohistochemistry staining of saline- and MPTP-treated animals at the level of SNpc. Statistical analyses were performed using one-way ANOVA. *p < 0.05, ***p < 0.001. Scale bar in B = 300 μm.