Figure 2

Age-related induction of MHC II and inflammation-response transcripts. Bioinformatic analysis of transcriptomic expression data identified significant upregulation the MHC II antigen presentation pathway and associated inflammatory signaling factors in hippocampal synaptosomes derived from both cognitively intact and cognitively impaired aged rats compared to adults (ANOVA with SNK post hoc testing, p < 0.05). Notably, no differences were observed between aged intact and aged impaired rats, which clustered separately from adults but did not cluster by cognitive status. Log-scaled gene expression is presented relative to the adult group mean per transcript (green: decreased; black: unchanged; red: increased).