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Table 5 Gene expression levels of age and cognitive status groups, presented as group mean (% of adult mean) ± SEM

From: Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

  CA1 CA3 DG synaptosomes (whole-hippocampus)
    Aged Aged    Aged Aged    Aged Aged    Aged Aged
Gene Adult Aged Intact Impaired Adult Aged Intact Impaired Adult Aged Intact Impaired Adult Aged Intact Impaired
C1s 100 ± 2.8 121 ± 6.1 125 ± 11.7 118 ± 6.6 100 ± 7.8 156 ± 7.6 159 ± 13.4 153 ± 9.3 100 ± 6.1 122 ± 4.8 117 ± 5.7 125 ± 6.9 100 ± 21.7 184 ± 21.8 182 ± 28.6 186 ± 35.3
C3 100 ± 6.6 200 ± 10.9 207 ± 16.4 194 ± 15.0 100 ± 7.9 196 ± 10.8 222 ± 17.8 178 ± 10.7 100 ± 8.1 169 ± 7.2 152 ± 10.2 181 ± 8.3 100 ± 23.2 347 ± 35.7 340 ± 27.6 355 ± 74.4
Serping1 100 ± 7.4 203 ± 13.4 218 ± 14.6 192 ± 20.2 100 ± 7.3 227 ± 11.5 252 ± 17.4 209 ± 13.1 100 ± 4.8 154 ± 6.3 149 ± 9.4 158 ± 8.7 100 ± 6.9 271 ± 12.4 279 ± 19.9 263 ± 15.5
Cd74 100 ± 7.7 561 ± 33.3 566 ± 44.5 558 ± 47.9 100 ± 10.9 361 ± 20.5 388 ± 37.6 340 ± 21.2 100 ± 7.7 243 ± 17.2 233 ± 36.7 249 ± 18.2 100 ± 28.8 658 ± 48.9 679 ± 46.7 635 ± 95.8
C4a 100 ± 7.1 177 ± 7.0 167 ± 11.1 185 ± 8.6 100 ± 4.8 151 ± 4.6 158 ± 6.2 147 ± 6.2 100 ± 9.7 135 ± 10.3 117 ± 15.2 147 ± 13.0 100 ± 17.7 418 ± 44.6 383 ± 31.6 459 ± 88.3
Ccr5 100 ± 5.2 108 ± 5.1 106 ± 5.2 110 ± 7.8 100 ± 3.1 121 ± 6.3 117 ± 7.3 125 ± 10.3 100 ± 6.9 99 ± 7.0 88 ± 7.1 106 ± 10.4 100 ± 17.9 196 ± 23.0 172 ± 18.8 220 ± 41.8
Cp 100 ± 5.4 93 ± 8.2 93 ± 6.9 93 ± 13.5 100 ± 3.9 156 ± 6.3 164 ± 9.2 150 ± 8.4 100 ± 9.2 110 ± 8.0 118 ± 13.7 103 ± 9.8 100 ± 10.8 167 ± 17.1 192 ± 28.6 146 ± 18.4
Ctse 100 ± 8.0 145 ± 10.2 141 ± 13.7 148 ± 14.4 100 ± 9.8 175 ± 7.4 173 ± 13.9 177 ± 8.7 100 ± 6.8 148 ± 6.8 140 ± 11.3 154 ± 8.4 100 ± 21.0 169 ± 12.0 181 ± 19.8 156 ± 11.4
Erbb3 100 ± 2.7 134 ± 5.1 143 ± 7.5 128 ± 6.5 100 ± 8.1 120 ± 5.1 128 ± 9.1 114 ± 5.6 100 ± 7.5 140 ± 7.8 129 ± 10.9 147 ± 10.3 100 ± 5.4 128 ± 4.0 126 ± 6.5 130 ± 4.6
Fcgr2b 100 ± 3.2 108 ± 7.9 103 ± 6.4 112 ± 13.0 100 ± 9.0 161 ± 5.2 163 ± 12.0 160 ± 3.6 100 ± 4.2 124 ± 11.0 125 ± 19.8 123 ± 13.2 100 ± 20.8 196 ± 15.4 208 ± 22.6 182 ± 21.2
Fcgr2a 100 ± 4.4 119 ± 4.8 116 ± 3.8 120 ± 7.7 100 ± 5.2 130 ± 4.2 130 ± 6.4 130 ± 5.9 100 ± 5.1 115 ± 3.8 109 ± 5.0 120 ± 5.0 100 ± 15.2 145 ± 11.4 143 ± 10.7 147 ± 22.8
Hla-dmb 100 ± 4.6 137 ± 4.6 133 ± 5.2 140 ± 7.3 100 ± 3.9 137 ± 3.7 139 ± 5.9 135 ± 4.9 100 ± 7.4 126 ± 4.4 115 ± 6.6 133 ± 4.7 100 ± 3.3 164 ± 8.3 157 ± 13.7 172 ± 8.4
Hla-dra 100 ± 7.9 404 ± 19.0 418 ± 28.1 395 ± 26.5 100 ± 14.7 302 ± 23.4 325 ± 47.0 285 ± 23.4 100 ± 9.7 181 ± 22.4 190 ± 43.4 175 ± 26.4 100 ± 24.0 630 ± 51.8 676 ± 67.9 575 ± 79.8
Hsbp1 100 ± 12.8 168 ± 9.6 165 ± 14.0 170 ± 13.6 100 ± 8.7 209 ± 11.0 225 ± 18.7 197 ± 13.0 100 ± 9.5 109 ± 11.5 80 ± 14.2 130 ± 13.8 100 ± 17.7 287 ± 25.1 313 ± 30.1 258 ± 40.9
Icam1 100 ± 5.5 155 ± 7.6 168 ± 11.9 146 ± 9.4 100 ± 5.6 143 ± 4.2 164 ± 13.3 131 ± 5.7 100 ± 12.2 102 ± 6.5 100 ± 13.5 102 ± 6.5 100 ± 11.1 146 ± 11.8 145 ± 16.7 147 ± 18.3
Lgals3 100 ± 4.9 264 ± 16.6 262 ± 21.4 266 ± 24.9 100 ± 7.3 198 ± 12.6 218 ± 16.3 184 ± 17.4 100 ± 10.5 184 ± 12.9 163 ± 10.0 200 ± 20.2 100 ± 21.4 342 ± 34.1 368 ± 54.6 303 ± 39.2
Hla-drb1 100 ± 11.0 713 ± 57.0 712 ± 96.9 713 ± 73.8 100 ± 9.7 439 ± 34.8 477 ± 73.9 412 ± 30.1 100 ± 14.1 291 ± 40.2 225 ± 44.4 342 ± 59.0 100 ± 7.6 1050 ± 67.3 1070 ± 97.4 1026 ± 100.2
S100a6 100 ± 2.8 203 ± 11.5 200 ± 16.2 206 ± 16.9 100 ± 7.5 221 ± 13.4 248 ± 20.9 202 ± 15.5 100 ± 16.3 110 ± 8.3 88 ± 15.5 123 ± 7.4 100 ± 9.0 152 ± 13.1 161 ± 24.3 145 ± 15.5
Tlr2 100 ± 6.3 106 ± 5.7 109 ± 9.8 104 ± 7.2 100 ± 11.2 154 ± 9.6 166 ± 18.9 146 ± 9.7 100 ± 16.6 172 ± 18.8 166 ± 36.7 176 ± 22.7 100 ± 13.0 164 ± 11.3 155 ± 19.2 173 ± 12.9
Tlr4 100 ± 2.7 135 ± 8.1 118 ± 12.8 143 ± 9.7 100 ± 8.4 196 ± 9.5 200 ± 19.7 193 ± 9.6 100 ± 8.7 119 ± 4.0 118 ± 5.9 120 ± 5.7 100 ± 8.3 151 ± 10.1 141 ± 4.9 160 ± 19.7
Tlr7 100 ± 3.5 134 ± 6.5 134 ± 17.2 135 ± 3.9 100 ± 8.1 173 ± 5.0 174 ± 9.6 172 ± 5.7 100 ± 11.6 94 ± 7.6 95 ± 11.6 93 ± 10.7 100 ± 13.3 169 ± 11.3 165 ± 16.6 173 ± 16.5