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Table 5 Gene expression levels of age and cognitive status groups, presented as group mean (% of adult mean) ± SEM

From: Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

 

CA1

CA3

DG

synaptosomes (whole-hippocampus)

   

Aged

Aged

  

Aged

Aged

  

Aged

Aged

  

Aged

Aged

Gene

Adult

Aged

Intact

Impaired

Adult

Aged

Intact

Impaired

Adult

Aged

Intact

Impaired

Adult

Aged

Intact

Impaired

C1s

100 ± 2.8

121 ± 6.1

125 ± 11.7

118 ± 6.6

100 ± 7.8

156 ± 7.6

159 ± 13.4

153 ± 9.3

100 ± 6.1

122 ± 4.8

117 ± 5.7

125 ± 6.9

100 ± 21.7

184 ± 21.8

182 ± 28.6

186 ± 35.3

C3

100 ± 6.6

200 ± 10.9

207 ± 16.4

194 ± 15.0

100 ± 7.9

196 ± 10.8

222 ± 17.8

178 ± 10.7

100 ± 8.1

169 ± 7.2

152 ± 10.2

181 ± 8.3

100 ± 23.2

347 ± 35.7

340 ± 27.6

355 ± 74.4

Serping1

100 ± 7.4

203 ± 13.4

218 ± 14.6

192 ± 20.2

100 ± 7.3

227 ± 11.5

252 ± 17.4

209 ± 13.1

100 ± 4.8

154 ± 6.3

149 ± 9.4

158 ± 8.7

100 ± 6.9

271 ± 12.4

279 ± 19.9

263 ± 15.5

Cd74

100 ± 7.7

561 ± 33.3

566 ± 44.5

558 ± 47.9

100 ± 10.9

361 ± 20.5

388 ± 37.6

340 ± 21.2

100 ± 7.7

243 ± 17.2

233 ± 36.7

249 ± 18.2

100 ± 28.8

658 ± 48.9

679 ± 46.7

635 ± 95.8

C4a

100 ± 7.1

177 ± 7.0

167 ± 11.1

185 ± 8.6

100 ± 4.8

151 ± 4.6

158 ± 6.2

147 ± 6.2

100 ± 9.7

135 ± 10.3

117 ± 15.2

147 ± 13.0

100 ± 17.7

418 ± 44.6

383 ± 31.6

459 ± 88.3

Ccr5

100 ± 5.2

108 ± 5.1

106 ± 5.2

110 ± 7.8

100 ± 3.1

121 ± 6.3

117 ± 7.3

125 ± 10.3

100 ± 6.9

99 ± 7.0

88 ± 7.1

106 ± 10.4

100 ± 17.9

196 ± 23.0

172 ± 18.8

220 ± 41.8

Cp

100 ± 5.4

93 ± 8.2

93 ± 6.9

93 ± 13.5

100 ± 3.9

156 ± 6.3

164 ± 9.2

150 ± 8.4

100 ± 9.2

110 ± 8.0

118 ± 13.7

103 ± 9.8

100 ± 10.8

167 ± 17.1

192 ± 28.6

146 ± 18.4

Ctse

100 ± 8.0

145 ± 10.2

141 ± 13.7

148 ± 14.4

100 ± 9.8

175 ± 7.4

173 ± 13.9

177 ± 8.7

100 ± 6.8

148 ± 6.8

140 ± 11.3

154 ± 8.4

100 ± 21.0

169 ± 12.0

181 ± 19.8

156 ± 11.4

Erbb3

100 ± 2.7

134 ± 5.1

143 ± 7.5

128 ± 6.5

100 ± 8.1

120 ± 5.1

128 ± 9.1

114 ± 5.6

100 ± 7.5

140 ± 7.8

129 ± 10.9

147 ± 10.3

100 ± 5.4

128 ± 4.0

126 ± 6.5

130 ± 4.6

Fcgr2b

100 ± 3.2

108 ± 7.9

103 ± 6.4

112 ± 13.0

100 ± 9.0

161 ± 5.2

163 ± 12.0

160 ± 3.6

100 ± 4.2

124 ± 11.0

125 ± 19.8

123 ± 13.2

100 ± 20.8

196 ± 15.4

208 ± 22.6

182 ± 21.2

Fcgr2a

100 ± 4.4

119 ± 4.8

116 ± 3.8

120 ± 7.7

100 ± 5.2

130 ± 4.2

130 ± 6.4

130 ± 5.9

100 ± 5.1

115 ± 3.8

109 ± 5.0

120 ± 5.0

100 ± 15.2

145 ± 11.4

143 ± 10.7

147 ± 22.8

Hla-dmb

100 ± 4.6

137 ± 4.6

133 ± 5.2

140 ± 7.3

100 ± 3.9

137 ± 3.7

139 ± 5.9

135 ± 4.9

100 ± 7.4

126 ± 4.4

115 ± 6.6

133 ± 4.7

100 ± 3.3

164 ± 8.3

157 ± 13.7

172 ± 8.4

Hla-dra

100 ± 7.9

404 ± 19.0

418 ± 28.1

395 ± 26.5

100 ± 14.7

302 ± 23.4

325 ± 47.0

285 ± 23.4

100 ± 9.7

181 ± 22.4

190 ± 43.4

175 ± 26.4

100 ± 24.0

630 ± 51.8

676 ± 67.9

575 ± 79.8

Hsbp1

100 ± 12.8

168 ± 9.6

165 ± 14.0

170 ± 13.6

100 ± 8.7

209 ± 11.0

225 ± 18.7

197 ± 13.0

100 ± 9.5

109 ± 11.5

80 ± 14.2

130 ± 13.8

100 ± 17.7

287 ± 25.1

313 ± 30.1

258 ± 40.9

Icam1

100 ± 5.5

155 ± 7.6

168 ± 11.9

146 ± 9.4

100 ± 5.6

143 ± 4.2

164 ± 13.3

131 ± 5.7

100 ± 12.2

102 ± 6.5

100 ± 13.5

102 ± 6.5

100 ± 11.1

146 ± 11.8

145 ± 16.7

147 ± 18.3

Lgals3

100 ± 4.9

264 ± 16.6

262 ± 21.4

266 ± 24.9

100 ± 7.3

198 ± 12.6

218 ± 16.3

184 ± 17.4

100 ± 10.5

184 ± 12.9

163 ± 10.0

200 ± 20.2

100 ± 21.4

342 ± 34.1

368 ± 54.6

303 ± 39.2

Hla-drb1

100 ± 11.0

713 ± 57.0

712 ± 96.9

713 ± 73.8

100 ± 9.7

439 ± 34.8

477 ± 73.9

412 ± 30.1

100 ± 14.1

291 ± 40.2

225 ± 44.4

342 ± 59.0

100 ± 7.6

1050 ± 67.3

1070 ± 97.4

1026 ± 100.2

S100a6

100 ± 2.8

203 ± 11.5

200 ± 16.2

206 ± 16.9

100 ± 7.5

221 ± 13.4

248 ± 20.9

202 ± 15.5

100 ± 16.3

110 ± 8.3

88 ± 15.5

123 ± 7.4

100 ± 9.0

152 ± 13.1

161 ± 24.3

145 ± 15.5

Tlr2

100 ± 6.3

106 ± 5.7

109 ± 9.8

104 ± 7.2

100 ± 11.2

154 ± 9.6

166 ± 18.9

146 ± 9.7

100 ± 16.6

172 ± 18.8

166 ± 36.7

176 ± 22.7

100 ± 13.0

164 ± 11.3

155 ± 19.2

173 ± 12.9

Tlr4

100 ± 2.7

135 ± 8.1

118 ± 12.8

143 ± 9.7

100 ± 8.4

196 ± 9.5

200 ± 19.7

193 ± 9.6

100 ± 8.7

119 ± 4.0

118 ± 5.9

120 ± 5.7

100 ± 8.3

151 ± 10.1

141 ± 4.9

160 ± 19.7

Tlr7

100 ± 3.5

134 ± 6.5

134 ± 17.2

135 ± 3.9

100 ± 8.1

173 ± 5.0

174 ± 9.6

172 ± 5.7

100 ± 11.6

94 ± 7.6

95 ± 11.6

93 ± 10.7

100 ± 13.3

169 ± 11.3

165 ± 16.6

173 ± 16.5