Figure 3

Quantitative features of edema build-up and resolution phases. Markers of BBB permeability (immunostaining of endogenous IgG extravasation and Evans Blue leakage) and pro-inflammatory cytokine (IL1β mRNA quantification) were found as early as 1 dpi (§, p < 0.05, Wilcoxon test) and were significantly increased during the build-up phase of the model compared to the resolution phase (*, p < 0.001, Mann Whitney). The resolution phase (7 to 20 dpi) was characterized by the formation of a glial scar with a significant increase of GFAP (mRNA quantification *, p < 0.05, Mann Whitney).