Figure 2

In treatment of human neuroimmunological disorders, anti-CD20-mediated B-cell depletion is associated with an increase in the frequency of regulatory T-cells. Peripheral blood mononuclear cells (PBMCs) were isolated from anti-CD20-treated or untreated patients with neuroimmunological disorders (see table 1). Frequency of regulatory T-cells is indicated as percentage of CD4⁺CD25⁺CD127^- within all CD4⁺ T-cells (a+b, black lines represent median; * p = 0.022).