Spontaneous movement is only reduced after traumatic axonal injury with additional hypoxia. Distance travelled (metres) was measured for 5 min as indicative of voluntary mobility in a novel open space. Diagrams depict: (A) Sham, (B) TAI, and (C) TAI+Hx. * indicates significant differences between testing at the pre-injury (Pre) or post-injury at days 3, 6 and 14. Distance travelled is shown as mean ± SEM, n = 10 per group per time point. Note the significant reduction in walking distance in TAI+Hx rats at 3 and 6 days as compared to TAI and sham rats. Data was analysed by 1-way ANOVA with Bonferroni post hoc test, with a p-value of < 0.05 considered significant.