Increase in brain edema does not differ in traumatic axonal injury rats with or without hypoxia. Brain water content was determined at 2, 24, 48, 72 and 96 h post-injury, and calculated as percentage of dry and wet ratio in the brain of sham (S), TAI alone, and TAI with hypoxia (TAI+Hx) animals. * indicates significant difference between groups. Both TAI and TAI+Hx showed similar increases in brain water content, and no differences were found between these groups. Data shown as mean ± SEM, n = 6 per group per time point. Data was analysed by 1-way ANOVA with Bonferroni post hoc test, with a p-value < 0.05 considered significant.