Figure 6From: Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury Metabolic alterations are exacerbated in rats exposed to traumatic axonal injury with additional hypoxia. Cerebral microdialysis samples were analysed between 21 h and 99 h after sham surgery, TAI and TAI with 30 min hypoxia (TAI+Hx). Data are expressed as both raw values and percentage changes from sham values for glucose (A, raw values; B, % change from sham levels), lactate (C, raw values; D, % change from sham levels) and glutamate (E, raw values; F, % change from sham). Shaded area in (C) and (D) represents the peak period of edema, which correlated with maximal lactate production. Overall a significant hypoglycaemic response was observed in both the TAI and TAI+Hx groups compared to shams (2-way repeated measures ANOVA, p < 0.05). Data shown as mean ± SEM, n = 5 per group per time point. Data was analysed by 2-way ANOVA repeated measures, with a p-value of < 0.05 considered significant.Back to article page