Table 1 Antibiotic intestinal decontamination (ATB) effect on stress-induced inflammatory, anti-inflammatory and oxidative/nitrosative parameters in control and CMS-exposed rats.

LPS (EU/mL)

0.2856 ± 0.027

0.3546 ± 0.006**

0.248 ± 0.022

0.3008 ± 0.016^#

LBP (ng/mL)

799.8 ± 39.75

955.6 ± 35.57*

840.0 ± 19.52

804.2 ± 32.97^#

TLR-4 (mRNA)

96.84 ± 2.618

109.8 ± 3.285**

102.5 ± 2.703

101.0 ± 1.278

TLR-4 (OD) (protein)

99.26 ± 4.455

116.9 ± 3.093**

88.09 ± 4.142

97.01 ± 3.162^##

MD-2 (mRNA)

98.01 ± 2.575

108.4 ± 2.178**

91.74 ± 2.432

96.86 ± 3.912^#

MD-2 (OD) (protein)

94.94 ± 2.977

108.6 ± 2.578*

102.6 ± 2.842

104.9 ± 4.381

NF-κB p65 Activity

(% Control)

100.0 ± 4.571

85.48 ± 3.277*

96.73 ± 15,33

71.66 ± 3.1**

NF-κB p65 (mRNA)

101.8 ± 2.546

94.21 ± 2.193*

90.28 ± 2.052

88.16 ± 2.879

NF-κB p65 (OD) (protein)

100.6 ± 3.363

87.23 ± 3.554*

103.2 ± 4.530

99.43 ± 3.442^#

IκBα (mRNA)

100.0 ± 4.286

118.7 ± 6.436*

95.55 ± 3.265

99.42 ± 5.101^#

COX-2 (mRNA)

99.89 ± 5.056

137.2 ± 8.159**

124.6 ± 7.084

107.1 ± 6.181^#

PGE₂

(pg/mg prot.)

45.14 ± 6.485

78.69 ± 12.24*

48.58 ± 8.973

36.75 ± 7.877^#

15d-PGJ₂

(pg/mg prot.)

83.45 ± 13.99

42.00 ± 6.775*

83.28 ± 13.78

107.8 ± 21.68^#

IL-1β (mRNA)

94.59 ± 4.000

114.0 ± 2.318**

95.91 ± 9.424

91.35 ± 3.886^##

MDA

(nmol/mg prot.)

0.00279 ± 0.000256

0.00372 ± 0.000285*

0.00187 ± 0.000142

0.00242 ± 0.000344^##