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Table 1 Description of post-mortem brain sections

From: Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis

Block

M/F

Age (Y)

DD (Y)

Cause of death

DFT (h)

Sample Type

ORO, hematoxylin Score

Summary observations on ORO-stained sections

1

F

68

-

Colo-rectal metastatic tumour

23

NC W, OV, R

0, 0

Normal white matter and cortical grey matter

2

M

49

-

Myocardial infarction and coronary artery thrombosis

11

NC W, PV, R

0, 0

Normal white matter and grey matter.

3

M

53

-

Cardiac arrest

19

NC W, OSv, R

0, 0

Normal white matter.

4

F

47

20

Bronchopneumonia

9

MS AQ, FSv, L

4, 3

White matter and grey matter surrounding active plaque. ORO+ cells in blood vessel walls and parenchyma.

5

F

47

20

Bronchopneumonia

9

MS AQ, PSv, L

5, 4

Large plaque with active and some subacute and chronic areas. Large perivascular cuffs. White and grey matter.

6

F

37

10

Bronchopneumonia

24

MS AQ, basal ganglia, L

3, 3

Large subacute plaque with perivascular cuffing; areas of grey matter.

7

F

71

32

Bronchopneumonia

19

MS SAQ, O pole Sv, L

2, 0

Hypocellular plaque surrounded by patchy abnormal-appearing white matter.

8

F

29

8

Bronchopneumonia

11

MS SAQ, cerebellum, R

1, 1

Large subacute plaque with hypercellular areas.

9

F

60

34

Renal failure

24

MS SAQ, TV, L

2, 4

Large subacute plaque with many large and small perivascular cuffs.

10

F

49

11

Bronchopneumonia

16

MS CQ, F pole V, R

0, 2

Large chronic plaque surrounded by pale abnormal white matter.

  1. Abbreviations:
  2. DD: disease duration; DFT: time between death and sample freezing; NC: normal control; W: white matter; MS: multiple sclerosis; AQ: active plaque; SAQ: subacute plaque; V: ventricular; Sv: subventricular; F: frontal; P: parietal; T: temporal; O: occipital; R: right; L: left.
  3. ORO and cuffing: Scored on a scale of 0 to 5 for ORO and haematoxylin staining; 0 is what would be expected in normal control white matter. Data is averaged from duplicate sections cut immediately before and after the serial sections cut.