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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins

Figure 1

Evaluating the role of αv integrins in mediating microglial adhesion to vitronectin. A. Adhesion to vitronectin of microglia derived from wild-type or β3/β5 integrin DKO mice in the presence or absence of an anti-αv blocking antibody was examined as described in Materials and Methods. Adhesion is expressed as the number of cells adherent within a given field of view after 30 minutes adhesion. All points represent the mean ± SEM of three experiments. B. Time course of adhesion to vitronectin for microglia derived from wild-type, β3 integrin KO, β5 integrin KO and β3/β5 integrin DKO mice. Adhesion is expressed as the number of cells adherent within a given field of view, after 15 and 30 minutes of cell adhesion. All points represent the mean ± SEM of three experiments. C. Phase pictures of wild-type, β3 integrin KO, β5 integrin KO and β3/β5 integrin DKO mice microglia adherent to vitronectin after 60 minutes. Scale bar = 50 μm. Note that none of the KO strains showed defects in their adhesion to vitronectin.

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